Our team from UCANR, UC Davis, USDA and Liphatech are delving into the critical issue of anticoagulant resistance in rodent populations, focusing on genetic mutations and their impact on pest control.

 

Rodenticide resistance, first identified in Norway rats in the 1970s, is now a widespread issue globally and in the U.S., particularly impacting first-generation anticoagulants (FGARs). The study emphasizes California's AB1788 law, which restricts second-generation rodenticide use, potentially increasing FGAR resistance.

 

Through field sampling and genetic analysis across California, researchers identified multiple rodent species and detected the Y25 mutation in the Vkorc1 gene, associated with resistance. The findings underscore the need for targeted resistance management strategies and further testing for metabolic resistance. This research aims to guide effective pest control practices and enhance understanding of resistance mechanisms in commensal rodents. 

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Stay tuned for more updates coming soon!